During the COVID-19 pandemic, different countries are showing strengths and weaknesses of both healthcare systems and technology access. Until now in Uruguay, COVID-19 has been very much under control. Evidence-based policies, a strong public health care system, and scientific innovations are believed to be the main factors of success. Uruguayan evidence-based policies consider several inputs, including scientific, medical-epidemiological, economic, and educational aspects. A Scientific Advisory Group regularly makes specific recommendations on health and data science to a team composed of high caliber figures in the government. This team evaluates and submits the reports and suggestions to the President of the Republic, for making final decisions concerning different responses to the pandemic and the economic reactivation. Designing and implementing such evidence-based policies require a vigorous scientific community and a government that gives importance to scientific and technical assessments, and an effective knowledge on brokering mechanisms.